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Scientific Evidence

Scientists examined and quantified Lactium® activity and efficacy on rats. They also tested Lactium on rats to see if it induced any of the side effects usually observed. Finally, in human clinical trials, Ingredia tested the Lactium stress-relieving effects on healthy subjects. These studies were made according to Good Clinical Practice guidelines in agreement with official ethical committees.

Results of Animal Studies:

  • Anti-stress efficacy confirmed
  • No side effects observed
  • No toxic effects observed
  • No weight variation

Clinical Studies:

  • 5 studies on 190 healthy volunteers
  • anti-stress efficacy confirmed at 167 mg/day

Tests and Measures used in the Studies:

  • Psychometric tests: Cattell's and Spielberger's anxiety scale
  • Mental provoked stress: Stroop test, attention-concentration test and Pacaud's mental rapidity test
  • Physical provoked stress: Cold pressor test
  • Hormonal assays: Cortisol and ACTH
  • Cardiovascular parameters: Blood pressure, heart rate

Lactium Anti-Stress Efficacy on Stressed Women

Stress Graph

This double-blind, cross-over study was carried out on 63 female volunteers -- 167 mg/day.

A significantly greater positive evolution of stress symptoms in five different areas was demonstrated in the group taking Lactium compared to the one taking the placebo: digestive (+ 29.5%), cardiovascular (+ 12.5%), intellectual (+ 28.1%), emotional (+20.3%) and social (+ 14.2%).

Lactium, at a dose of 167 mg/day, was particularly efficient for subjects who demonstrated the highest initial intensity of symptoms. This was true after a 15- and 30-day treatment.